Gout is hereditary
Gout is a congenital metabolic genetic defect disease, which has been clinically confirmed.
About 10% to 25% of gout patients have a family history.10% to 25% of the close relatives of gout patients have hyperuricemia.
If one parent has gout, 40% to 50% of the children will have gout. And if both parents have gout, the children will have gout up to 75%.
Therefore, it is believed that primary gout is hereditary.
The essence of gout genetic defects is gene mutations
The essence of gout genetic defects is the same as other genetic diseases, mainly gene mutations.
Genes exist on human cell chromosomes, they carry genetic codes, control the synthesis of proteins and enzymes, and thus affect the metabolism of uric acid.
Gout is caused by mutations in the genes of some enzymes that control the production of uric acid, which leads to increased uric acid production.
But the specific inheritance mode is still unclear, and there is a lack of reliable and sensitive genetic markers.
Gout may run in families
At present, except for a very small number of cases of gout caused by purine metabolic enzyme defects, which have been confirmed to be linked recessive inheritance and familial adolescent hyperuricemia nephropathy which is autosomal recessive inheritance, the inheritance mode of most primary gout is still uncertain.
Although gout may be highly prevalent in families, it does not mean that if the father has gout, the children will definitely get gout. Gout patients have the right to have children, and it does not affect the sex life of the couple.
However, in the first-degree relationship, if there are two cases of gout in the family, the incidence of gout in the offspring of this family will be significantly increased, and regular examinations are required.